Dr Michael Randles

Academic Lead
Chester Medical School
m.randles@chester.ac.uk
Dr Michael Randles

Michael is Year 1 Lead for MBChB Graduate Entry Medicine. He has a PhD in Medicine from the University of Manchester. In addition, he is a Fellow of the Institute of Biomedical Science, a Fellow of the Higher Education Academy and a PGCLTHE from De Montfort University.

Michael’s academic career commenced at The University of Bristol where he studied for a BSc in Biochemistry with Medical Biochemistry, followed by PhD in Medicine from The Wellcome Trust Centre for Cell-Matrix Research at the University of Manchester. Subsequently, Michael worked as a lecturer and completed his PGCLTHE at De Montfort University, where he acted as Deputy Programme Lead for BSc Biomedical Science. He has also previously led the BSc Biomedical Science programme at the University of Chester. Michael has a continued research interest investigating Alport syndrome, a disease that impacts basement membranes in the eyes, ears and kidney. Michael use mass spectrometry-based proteomics to investigate matrix signatures of glomerular diseases. Michael is the Phase I Lead for MB ChB Graduate Entry Medicine. 

Michael has substantial experience teaching undergraduate and postgraduate Biomedical Science programmes. His areas of teaching include cell biology, physiology, genetics and proteomics. He is most passionate about cell-matrix interactions and investigating these molecular mechanisms in the context of kidney diseases.

Michael's research focuses on investigating the glomerular matrix in kidney disease using mass spectrometry-based proteomics, he has a number of high impact publications.

Di Mambro A, Arroyo-Berdugo Y, Fioretti T, Randles M, Cozzuto L, Rajeeve V, Cevenini A, Austin MJ, Esposito G, Ponomarenko J, Lucas CM, Cutillas P, Gribben J, Williams O, Calle Y, Patel B, Esposito MT. SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML. Oncogene. 2023 Oct 27. doi: 10.1038/s41388-023-02840-1. Epub ahead of print. PMID: 37891368.

Randles MJ+, Lausecker F+, Kong Q, Suleiman H, Reid G, Kolatsi-Joannou M, et al. A signature of altered extracellular matrix in kidney ageing and disease. J Am Soc Nephrol. 2021.

Falcone S, Nicol T, Blease A, Randles MJ, Angus E, et al. A novel model of nephrotic syndrome results from a point mutation in Lama5 and is modified by genetic background. Kidney Int. 2021.

Randles, M.J., Lausecker, F., Humphries, J., Byron, A., Clark, S., & Miner, J. et al. (2020). Basement membrane ligands initiate distinct signalling networks to direct cell shape. Matrix Biology, 90, 61-78. doi: 10.1016/j.matbio.2020.02.005

Rheault, M., Savige, J., Randles, M.J., Weinstock, A., Stepney, M., & Turner, A. et al. (2019). The importance of clinician, patient and researcher collaborations in Alport syndrome. Pediatric Nephrology, 35(5), 733-742. doi: 10.1007/s00467-019-04241-7

  1. Fresquet, T.A. Jowitt, E.A. McKenzie, M.D. Ball,M.J. Randles, R. Lennon, P.E. Brenchley (2017)PLA2R binds to the annexin A2-S100A10 complex in human podocytes. Scientific Reports.
  2. Tabatabaeifar, T. Wlodkowski, I. Simic, H. Denc, G. Mollet, S. Weber, J.J. Moyers, B. Brühl,M.J. Randles, R. Lennon, C. Antignac and F. Schaefer (2017)An inducible mouse model of podocin-mutation-related nephrotic syndrome. PLoS One.
  3. Peña-Fernández, T. Sgamma, C. Young,M.J. Randles, C. Del Águila, C. Hurtado, M. Evans, N. Potiwat, F. Izquierdo, M.A. Peña, J. Coope, M. Armstrong, A. Bhambra (2017)Building a DMU e-biology resource for health science students. ICERI2017 Proceedings.
  4. Coletta, N. A. Roberts,M. J. Randles, A. Morabito and A. S. Woolf (2016)Exogenous transforming growth factor -β 1 enhances smooth muscle differentiation in embryonic mouse jejunal explants. Journal of Tissue Engineering and Regenerative Medicine.
  5. J. Randles, S. Collinson, T. Starborg, A. Mironov, M. Krendel, T. Wlodkowski, F. Schaffer, E. Koenigshausen, L. Sellin, I. Roberts, K. E. Kadler, J. H. Miner and R. Lennon (2016)Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury.Scientific Reports.
  6. J. Randles(2016)The kidney filtration barrier. Biological sciences review, volume 28.3.
  7. J. Randles,M. J. Humphriesand R. Lennon (2016) Proteomic definitions of basement membrane composition in health and disease. Matrix biology.
  8. J. Randles, A.S.Woolf, J.L. Huang, A Byron, J.D. Humphries, K.L. Price, M Kolatsi-Joannou, S. Collinson, T. Denny, D. Knight, A. Mironov, T. Starborg, R. Korstanje, M.J. Humphries, D.A. Long, R. Lennon (2015) Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization. Journal of the American Society of Nephrology.
  9. Lennon, H. M. Stuart, A. Bierzynska, M. J. Randles, B. Kerr, K. A. Hillman, G. Batra, J. Campbell, H. Storey, F. A. Flinter, A. Koziell, G. I. Welsh, M. A. Saleem, N. J. Webb, A. S. Woolf (2015)Coinheritance of COL4A5 and MYO1E mutations accentuate the severity of kidney disease.  Pediatric Nephrology.
  10. Lennon,M. J. Randles(2015) Applying proteomics to investigate basement membranes in health and disease. Basement membranes the book.
  11. J. Randles+, A. Byron+, J. D. Humphries, A. Mironov, H. Hamidi, S. Harris, P. W. Mathieson, M. A. Saleem, S. S. Satchell, R. Zent, M. J. Humphries and R. Lennon (2014)Glomerular Cell Cross-Talk Influences Composition and Assembly of Extracellular Matrix.Journal of the American Society of Nephrology.
  12. Lennon,M. J. Randlesand M. J. Humphries (2014) The importance of podocyte adhesion for a healthy glomerulus. Frontiers in endocrinology.
  13. Lennon, A. Byron, J. D. Humphries,M. J. Randles, A. Carisey, S. Murphy, D. Knight, P. E. Brenchley, R. Zent and M. J. Humphries (2014)Global Analysis Reveals the Complexity of the Human Glomerular Extracellular Matrix. Journal of the American Society of Nephrology.
  • BSc, Biochemistry with Medical Biochemistry, University of Bristol, 2011
  • PhD, Medicine, The University of Manchester, 2015
  • PGCLTHE, De Montfort University Leicester, 2018

Professional Body Membership

  • Fellow of the Higher Education Academy (FHEA)
  • International Society of Matrix Biology (ISMB)
  • Member of Institute of Biomedical Science (MIBMS)