Dr Svetlana Mysina

Senior Lecturer
Chester Medical School
s.mysina@chester.ac.uk
Dr Svetlana Mysina

Svetlana came into higher education from multidisciplinary cancer research. Following her undergraduate degree in biology in Russia, she received her PhD in haematology in Germany, then worked as a postdoc in Glasgow and Newcastle upon Tyne until her full-time educational career  started at the University of Sunderland (2013) where she was delivering teaching to Biomedical Science students.

My PhD project ‘Ion Channel in the Regulation of Erythrocyte Apoptosis’ under supervision of Professor F. Lang was performed in Physiology Institute, University of Tübingen, Germany.

As a postdoc I led project “Is survival of primitive, quiescent stem cells from patients with chronic myeloid leukemia Bcr-Abl dependent or not?” in world leading chronic myeloid leukaemia research group under supervision of Professor Tessa Holyoake in Beatson Cancer Institute, The University of Glasgow.

After I accepted challenge as a Research Associate in leading Leukemia Research Group headed by Professor Josef Vormoor, and Professor Olaf Heidenreich, Northern Institute for Cancer Research, Newcastle University.

At Newcastle University I have met decision to become a teacher in Higher Education. Here I accomplished my training and was awarded Fellow of Higher Education Academy.

For three years I was an invited lecturer at the Newcastle University, Northumbria University and the University of Sunderland teaching on undergraduate and postgraduate programmes at Dental School, Medical School, Biomedical Sciences and Health Sciences. My career path led me to the University of Sunderland where I was lecturing until I have accepted post at Chester Medical School.

I am a programme leader for Master Oncology programme (MD7011);  leading MS modules MD7003 Clinical Medicine and MD7012 Therapeutic Advances in Oncology.

At the beginning of my research career I was focused on apoptosis like processes in erythrocytes. As a postdoc I researched mechanisms of cancer in chronic myeloid leukaemia. My interests changed then to the paediatric leukaemia and neuroblastoma research. I am looking to expand my scientific expertise into clinical medicine and educational research.

John Clark-Corrigall, Svetlana Myssina, Martin Michaelis, Jindrich Cinatl Jr., Shafiq Ahmed & Jane Carr-Wilkinson (2022). Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance, Cancer Investigation, DOI: 10.1080/07357907.2022.2136682

Svetlana Myssina, Martin Michaelis, Jindrich Cinatl, jr., John Clark-Corrigall, Shafiq U. Ahmed, Jane Carr-Wilkinson. Elevated expression of LGR5 and WNT signalling factors in neuroblastoma cells with acquired drug resistance (in submission). 

John Clark-Corrigall, Svetlana Myssina, Masood Zaka, Shafiq. U. Ahmed, Jane Carr-Wilkinson. The Role of Stem Cell Related Genes in Acquired Drug Resistance (in submission).

Elsana H, Mysina S, Elkordy EA, Carr-Wilkinson J, Elkordy AA. Insights into the Influences of Carboxymethyl-β-Cyclodextrin on DNA Formulations Characteristics and Gene Transfection Efficiency. Curr Drug Deliv. 2018;15(6):867-878. PubMed PMID: 29484997.

Hamilton A, Helgason GV, Schemionek M, Zhang B, Myssina S, Allan EK, Nicolini FE, Müller-Tidow C, Bhatia R, Brunton VG, Koschmieder S, Holyoake TL. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood. 2011 Dec 19. [Epub ahead of print] PubMed PMID: 22184410.

Hamilton A, Alhashimi F, Myssina S, Jorgensen HG, Holyoake TL. Optimization of methods for the detection of BCR-ABL activity in Philadelphia-positive cells. Exp Hematol. 2009 Mar;37(3):395-401. Epub 2009 Jan 9. PubMed PMID: 19135772.

Myssina S, Helgason GV, Serrels A, Jørgensen HG, Bhatia R, Modi H, Baird JW, Mountford JC, Hamilton A, Schemionek M, Koschmieder S, Brunton VG, Holyoake TL. Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells. Exp Hematol. 2009 Feb;37(2):206-14. Epub 2008 Dec 18. PubMed PMID: 19100678.

Lang F, Birka C, Myssina S, Lang KS, Lang PA, Tanneur V, Duranton C, Wieder T, Huber SM. Erythrocyte ion channels in regulation of apoptosis. Adv Exp Med Biol. 2004;559:211-7. Review. PubMed PMID: 18727242.

Hamilton A, Elrick L, Myssina S, Copland M, Jørgensen H, Melo JV, Holyoake T. BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry. Leukemia. 2006 Jun;20(6):1035-9. PubMed PMID: 16572205.

Lang PA, Kempe DS, Myssina S, Tanneur V, Birka C, Laufer S, Lang F, Wieder T, Huber SM. PGE(2) in the regulation of programmed erythrocyte death. Cell Death Differ. 2005 May;12(5):415-28. PubMed PMID: 15746942.

Lang PA, Kempe DS, Tanneur V, Eisele K, Klarl BA, Myssina S, Jendrossek V, Ishii S, Shimizu T, Waidmann M, Hessler G, Huber SM, Lang F, Wieder T.Stimulation of erythrocyte ceramide formation by platelet-activating factor. J Cell Sci. 2005 Mar 15;118(Pt 6):1233-43. Epub 2005 Mar 1. PubMed PMID: 15741229.

Shumilina E, Lampert A, Lupescu A, Myssina S, Strutz-Seebohm N, Henke G, Grahammer F, Wulff P, Kuhl D, Lang F. Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1. J Cell Physiol. 2005 Jul;204(1):87-98. PubMed PMID: 15605386.

Baltaev R, Strutz-Seebohm N, Korniychuk G, Myssina S, Lang F, Seebohm G. Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes. Pflugers Arch. 2005 Apr;450(1):26-33. Epub 2004 Dec 1. PubMed PMID: 15578212.

Myssina S, Lang PA, Kempe DS, Kaiser S, Huber SM, Wieder T, Lang F. Cl-channel blockers NPPB and niflumic acid blunt Ca(2+)-induced erythrocyte'apoptosis'. Cell Physiol Biochem. 2004;14(4-6):241-8. PubMed PMID: 15319527.

Birka C, Lang PA, Kempe DS, Hoefling L, Tanneur V, Duranton C, Nammi S, Henke G, Myssina S, Krikov M, Huber SM, Wieder T, Lang F. Enhanced susceptibility to erythrocyte "apoptosis" following phosphate depletion. Pflugers Arch. 2004 Aug;448(5):471-7. Epub 2004 May 20. PubMed PMID: 15156318.

Lang KS, Myssina S, Lang PA, Tanneur V, Kempe DS, Mack AF, Huber SM, Wieder T, Lang F, Duranton C. Inhibition of erythrocyte phosphatidylserine exposure by urea and Cl-. Am J Physiol Renal Physiol. 2004 Jun;286(6):F1046-53.PubMed PMID: 15130896.

Lang PA, Kaiser S, Myssina S, Birka C, Weinstock C, Northoff H, Wieder T, Lang F, Huber SM. Effect of Vibrio parahaemolyticus haemolysin on human erythrocytes. Cell Microbiol. 2004 Apr;6(4):391-400. PubMed PMID:15009030.

Lang PA, Warskulat U, Heller-Stilb B, Huang DY, Grenz A, Myssina S, Duszenko M, Lang F, Häussinger D, Vallon V, WiederT. Blunted apoptosis of erythrocytes from taurine transporter deficient mice. Cell Physiol Biochem. 2003;13(6):337-46.PubMed PMID: 14631140.

Lang KS, Myssina S, Brand V, Sandu C, Lang PA, Berchtold S, Huber SM, Lang F, Wieder T. Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell Death Differ. 2004 Feb;11(2):231-43. PubMed PMID: 14615798.

Lang PA, Kaiser S, Myssina S, Wieder T, Lang F, Huber SM. Role of Ca2+-activated K+ channels in human erythrocyte apoptosis. Am J Physiol Cell Physiol. 2003 Dec;285(6):C1553-60. PubMed PMID: 14600080.

Myssina S, Huber SM, Birka C, Lang PA, Lang KS, Friedrich B, Risler T, Wieder T, Lang F. Inhibition of erythrocyte cation channels by erythropoietin. J Am Soc Nephrol. 2003 Nov;14(11):2750-7. PubMed PMID: 14569084.

Lang F, Lang KS, Wieder T, Myssina S, Birka C, Lang PA, Kaiser S, Kempe D, Duranton C, Huber SM. Cation channels, cell volume and the death of an erythrocyte. Pflugers Arch. 2003 Nov;447(2):121-5. Epub 2003 Aug 7. Review. PubMed PMID: 12905029.

Lang KS, Duranton C, Poehlmann H, Myssina S, Bauer C, Lang F, Wieder T, Huber SM. Cation channels trigger apoptotic death of erythrocytes. Cell Death Differ. 2003 Feb;10(2):249-56. PubMed PMID: 12700653.

Lang KS, Myssina S, Tanneur V, Wieder T, Huber SM, Lang F, Duranton C. Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride. Naunyn Schmiedebergs Arch Pharmacol. 2003 Apr;367(4):391-6. Epub 2003 Mar 4.PubMed PMID: 12690431.

Lang KS, Roll B, Myssina S, Schittenhelm M, Scheel-Walter HG, Kanz L, Fritz J, Lang F, Huber SM, Wieder T. Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency. Cell Physiol Biochem. 2002;12(5-6):365-72. PubMed PMID: 12438773.

Fellowship of Higher Education Academy (FHEA).

PhD in Haematology, Eberhard Karls Universität Tübingen, Germany.

Diploma in Biology (Human Genetics), Southern Federal University, Russia.