Noha Ziedan | University of Chester

Noha is a senior Lecture and the programme leader for the BSc chemistry programme.

Noha teaches organic chemistry, analytical chemistry and medicinal chemistry across the programme.

Noha’s main focus of research activity is the discovery and development of novel small active molecules as drug candidates to combat disease with primary interest in cancer research. Her research interests can be divided into the following categories:

Selective apoptosis induction in cancer cells
Protein-protein interactions as cancer drug target
Development of kinesin inhibitors as anticancer agents
Development of COVID-19 main protease inhibitors

QSAR-driven screening uncovers and designs novel pyrimidine-4,6-diamine derivatives as potent JAK3 inhibitors 7 Dec 2023 Journal of Biomolecular Structure and Dynamics Taylor & Francis Faris A, Ibrahim IM, Alnajjar R, Hadni H, Bhat MA, Yaseen M, Chakraborty S, Alsakhen N, Shamkh IM, Mabood F, Naglah AM, Ullah I, Ziedan N, Elhallaoui M.
Identification of Disalicyloyl Curcumin as a Potential DNA Polymerase Inhibitor for Marek’s Disease Herpesvirus: A Computational Study Using Virtual Screening and Molecular Dynamics Simulations 12 Sep 2023 Molecules MDPI Cherif A, Basharat Z, Yaseen M, Bhat MA, Uddin I, Ziedan N, Mabood F, Sadfi-Zouaoui N, Messaoudi A.
Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights 20 Jul 2023 Journal of Enzyme Inhibition and Medicinal Chemistry Taylor & Francis Hamdi A, Yaseen M, Ewesa WA, Bhat MA, Ziedan N, El-Shafey HW, Mohamed AAB, Elnagar MR, Haikalh A, Othmana DIA, Elgazari AA, Abusabaaj AHA, Abdelrahman KS, Soltan OM, Elbadawi MM.
How does camel milk fat profile compare with that of human milk fat to serve as a substitute for human milk? 24 Jun 2023 International Dairy Journal Elsevier Bakry IA, Wei W, Farag MA, Korma SA, Khalifa I, Ziedan N, Mahdi HK, Jin J, Wang X.
A Comprehensive Review of the Composition, Nutritional Value, and Functional Properties of Camel Milk Fat 13 Sep 2021 Foods MDPI Bakry IA, Yang L, Farag MA, Korma SA, Khalifa I, Cacciotti I, Ziedan N, Jin J, Jin Q, Wei W, Wang X.
BCR-ABL Tyrosine Kinase Inhibitors as Candidates for the Treatment of COVID-19: Molecular Docking, Pharmacophore Modeling, ADMET Studies 8 Aug 2021 Biointerface Research in Applied Chemistry AMG Transcend Association Attia MS, Hassanballah MY, Negida A, Sebaiy MM, Ziedan N.
Changes in the fatty acid content of Egyptian human milk across the lactation stages and in comparison with Chinese human milk May 2021 European Food Research and Technology 247(5):1035-1048 Springer Nature Bakry IA, Korma SA, Wei W, Nafea AE, Mahdi AA, Ziedan NI, Wang X.
Design, Synthesis and Evaluation of New Bioactive Oxadiazole Derivatives as Anticancer Agents Targeting Bcl-2 26 Nov 2020 International Journal of Molecular Sciences MDPI Hamdy R, Elseginy SA, Ziedan N, El-Sadek M, Lashin E-S, Jones AT, Westwell AD.
Developing A High-performance Liquid Chromatography Method for Simultaneous Determination of Loratadine and its Metabolite Desloratadine in Human Plasma 24 Nov 2019 Current Drug Metabolism Bentham Science Co-authors: Sebaiy MM, Ziedan N.
New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2 2 Apr 2019 MDPI Co-authors:Hamdy R, Elseginy SA, Ziedan N, Jones AT, Westwell AD.
Virtual screening, SAR, and discovery of 5‐(indole‐3‐yl)‐2‐[(2‐nitrophenyl)amino] [1,3,4]‐oxadiazole as a novel Bcl‐2 inhibitor Jul 2017 Chemical Biology & Drug Design 90(1):147-155 Wiley Co-authors:Ziedan NI, Hamdy R, Cavaliere A, Kourti M, Prencipe F, Brancale A, Jones AT, Westwell AD.
Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents Feb 2017 Bioorganic & Medicinal Chemistry Letters 27(4):1037-1040 Elsevier Co-authors: Hamdy R, Ziedan NI, Ali S, Bordoni C, El-Sadek M, Lashin E, Brancale A, Jones AT, Westwell AD.
Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents Apr 2013 Bioorganic & Medicinal Chemistry Letters 23(8):2391-2394 Elsevier Co-authors:Hamdy R, Ziedan N, Ali S, El-Sadek M, Lashin E, Brancale A, Jones AT, Westwell AD.
ChemInform Abstract: Synthesis and Evaluation of Indole‐Containing 3,5‐Diarylisoxazoles as Potential Pro‐Apoptotic Antitumor Agents. 19 Mar 2013 ChemInform 44(12):no Wiley Co-authors: Tohid SFM, Ziedan NI, Stefanelli F, Fogli S, Westwell AD.
Synthesis and evaluation of indole-containing 3,5-diarylisoxazoles as potential pro-apoptotic antitumour agents Oct 2012 European Journal of Medicinal Chemistry 56:263-270 Elsevier Co-authors: Tohid SFM, Ziedan NI, Stefanelli F, Fogli S, Westwell AD.
ChemInform Abstract: Design, Synthesis and Pro‐apoptotic Antitumor Properties of Indole‐Based 3,5‐Disubstituted Oxadiazoles. 18 Jan 2011 ChemInform42(3): no Wiley Co-authors: Ziedan NI, Stefanelli F, Fogli S, Westwell AD.
Design, synthesis and pro-apoptotic antitumour properties of indole-based 3,5-disubstituted oxadiazoles Oct 2010 European Journal of Medicinal Chemistry 45(10):4523-4530 Elsevier Co-authors: Ziedan NI, Stefanelli F, Fogli S, Westwell AD.
The development of pro-apoptotic cancer therapeutics. Jun 2008 Mini-Reviews in Medicinal Chemistry 8(7):711-718 Bentham Science Publishers Co-authors: Ziedan NI, Kadri H, Westwell AD.
SYNTHESIS OF NEW 1,2,4-TRIAZOLOQUINAZOLINE DERIVATIVES AS CNS MODULATORS 1 Dec 2006 Zagazig Journal of Pharmaceutical Sciences15(2):19-28 Egyptian Knowledge Bank Co-authors: Ziedan N, El-Shanawani A, El-Adl S, Sakr S.